Intra-amniotic Hypertonic Saline

Termination of midtrimester pregnancies by intra-amniotic injection of hypertonic saline.

Amniocentesis and intra-amniotic injection of hypertonic saline to terminate pregnancy in the second trimester has at~ tained great importance in recent [Years. That such a method was not accepted or currently used in leading obstetric institutiolll3 can be easily demonstrated. In Scandinavia, where an average of 3,354 pregnancies were legally terminated annually from 1955 to 1965, abdominal by...

Intra-amniotic hypertonic saline (5 per cent) for mid trimester abortion.

Induction of labour by intra-amniotic injection of hypertonic glucose.

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Hypertonic saline and stroke.

Cytotoxic brain edema—swelling of nerve and glial cells—is among the very early pathophysiologic sequelae of focal cerebral ischemia. Once cell swelling has exhausted the cerebral compliance, intracranial pressure increases and, thereby, causes secondary ischemia. Hypertonic solutions, mannitol in particular, have long been used to reduce intracranial pressure. More recently, hypertonic saline ...

Hypertonic saline for craniotomy?

IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...